Understanding how HIV-1 persists in certain immune cells
Revealing HIV-1 persistence in myeloid cell reservoirs
This study is looking at how HIV-1 hides in certain immune cells in the body, even when people are on treatment, and aims to find new ways to understand these hidden reservoirs so we can improve HIV treatment in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11054686 on NIH RePORTER |
What this research studies
This research investigates the persistence of HIV-1 in myeloid cell reservoirs, which are immune cells that can harbor the virus even during antiretroviral therapy (ART). The study aims to develop new methods to analyze these reservoirs in living subjects, focusing on the role of tissue resident macrophages and other myeloid cells. By examining the composition and dynamics of these cells, researchers hope to gain insights into how HIV-1 remains hidden and can potentially lead to treatment breakthroughs. The approach includes innovative techniques to track the origins of viral particles in the bloodstream.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who are undergoing antiretroviral therapy and have experienced treatment interruptions.
Not a fit: Patients who are newly diagnosed with HIV or those not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for eradicating HIV-1 from the body and enhancing treatment options for patients.
How similar studies have performed: Previous research has shown promise in understanding viral reservoirs, but this specific approach to studying myeloid cell contributions is relatively novel.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Stevenson, Mario — University of Miami School of Medicine
- Study coordinator: Stevenson, Mario
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.