Understanding how HIV-1 packages its RNA genome
Ribonucleoprotein complexes involved in the late phase of HIV-1 replication
['FUNDING_CAREER'] · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · NIH-11007822
This study looks at how the HIV virus puts together its genetic material to make new copies of itself, focusing on how the virus's RNA gets to the right spot in the cell, and it hopes to find new ways to help treat HIV.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE COUNTY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11007822 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which HIV-1 assembles its RNA genome during the virus replication process. It focuses on how viral RNA is trafficked to the cell membrane and anchored by viral proteins, which are crucial for the formation of new virus particles. The study employs advanced techniques like nuclear magnetic resonance spectroscopy to explore the structural interactions involved in this process. By identifying these interactions, the research aims to uncover potential new targets for HIV treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are interested in contributing to advancements in HIV treatment.
Not a fit: Patients who are not infected with HIV or those who are not currently undergoing treatment for HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapeutic strategies for treating HIV/AIDS.
How similar studies have performed: Previous research has shown promise in understanding viral assembly mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE COUNTY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOLLMANN, NELE MERRET — UNIVERSITY OF MARYLAND BALTIMORE COUNTY
- Study coordinator: HOLLMANN, NELE MERRET
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome