Understanding how HIV-1 packages its RNA genome
Official title: Ribonucleoprotein complexes involved in the late phase of HIV-1 replication
Funded at University of Maryland Baltimore County · NIH-11007822 · Data updated 2026-11-12
This study looks at how the HIV virus puts together its genetic material to make new copies of itself, focusing on how the virus's RNA gets to the right spot in the cell, and it hopes to find new ways to help treat HIV.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore County NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $136,350 |
| NIH project number | 1K99AI186598-01 |
| Project ID | NIH-11007822 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are interested in contributing to advancements in HIV treatment.
✕Less likely to help
Patients who are not infected with HIV or those who are not currently undergoing treatment for HIV may not benefit from this research.
What this research studies
This research investigates the mechanisms by which HIV-1 assembles its RNA genome during the virus replication process. It focuses on how viral RNA is trafficked to the cell membrane and anchored by viral proteins, which are crucial for the formation of new virus particles. The study employs advanced techniques like nuclear magnetic resonance spectroscopy to explore the structural interactions involved in this process. By identifying these interactions, the research aims to uncover potential new targets for HIV treatment.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapeutic strategies for treating HIV/AIDS.
How similar studies have gone: Previous research has shown promise in understanding viral assembly mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Maryland Baltimore County
Baltimore, United States Active
Researchers
- Principal investigator: Hollmann, Nele Merret — University of Maryland Baltimore County
- Study coordinator: Hollmann, Nele Merret
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.