Understanding how HIV-1 matures into an infective virus
Official title: Determining the molecular mechanisms of HIV-1 maturation
Funded at University of Delaware · NIH-10907824 · Data updated 2026-11-12
This study is looking at how the HIV virus changes and becomes infectious, using advanced technology to understand the important roles of certain proteins and membranes, which could help create better treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $577,308 |
| NIH project number | 5R01AI178846-02 |
| Project ID | NIH-10907824 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection.
✕Less likely to help
Patients who are not infected with HIV or who do not have risk factors for HIV infection may not benefit from this research.
What this research studies
This research investigates the molecular processes that occur during the maturation of HIV-1, which is crucial for the virus to become infectious. By using advanced molecular dynamics simulations, the study aims to uncover the structural changes and interactions that take place as the virus transitions from an immature to a mature state. The research focuses on the roles of specific proteins and lipid membranes in this process, providing insights that could lead to new therapeutic strategies. Patients may benefit from a deeper understanding of HIV maturation, which could inform the development of more effective treatments.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing HIV infection or improving treatment options for those living with HIV.
How similar studies have gone: Previous research has shown success in understanding viral maturation processes, but this specific approach using molecular dynamics simulations is relatively novel.
Where this research is happening
-
University of Delaware
Newark, United States Active
Researchers
- Principal investigator: Perilla Jimenez, Juan Roberto — University of Delaware
- Study coordinator: Perilla Jimenez, Juan Roberto
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.