Understanding how HIV-1 interacts with the immune system.
Official title: Determinants of HIV-1 innate immune sensing and its role in shaping the lymphoid environment.
Funded at Scripps Research Institute, the · NIH-10886726 · Data updated 2026-11-12
This study is looking at how the HIV-1 virus manages to dodge the body's immune defenses, especially by exploring certain proteins that help it escape detection, with the goal of finding ways to boost the immune response against the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 12, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $839,256 |
| NIH project number | 5R01AI177265-02 |
| Project ID | NIH-10886726 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV-1 or those at high risk of HIV infection.
✕Less likely to help
Patients who are not infected with HIV-1 or those who do not have risk factors for HIV infection may not benefit from this research.
What this research studies
This research investigates how HIV-1 evades the immune system's initial defenses, particularly focusing on the role of specific proteins in the virus that help it bypass immune responses. By studying the interactions between HIV-1 and immune cells, especially dendritic cells, the research aims to uncover why some immune responses fail to prevent the virus from spreading. The methodology includes examining the mechanisms by which HIV-1 proteins interact with cellular factors, which could lead to new insights into improving immune responses against the virus.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the immune response against HIV-1, potentially improving treatment and prevention methods.
How similar studies have gone: Previous research has shown promise in understanding HIV-1's interactions with the immune system, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Yoh, Sunnie — Scripps Research Institute, the
- Study coordinator: Yoh, Sunnie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.