Understanding how HIV-1 interacts with host cells during infection
Project 2. Immune evasion, trafficking, and nuclear import
This study is looking at how the HIV-1 virus gets into our cells and hides from our immune system, which could help find better ways to prevent or treat HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11078371 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the HIV-1 virus enters and integrates into host cells, focusing on the role of the virus's capsid. The project aims to uncover how the capsid interacts with host immune proteins and navigates through cellular structures to reach the nucleus. By using advanced techniques like CryoEM and NMR, the researchers will provide detailed insights into the virus's behavior and its evasion of the immune system. This knowledge could lead to new strategies for preventing or treating HIV infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are seeking new treatment options or have not responded well to existing therapies.
Not a fit: Patients who are not infected with HIV or those who have advanced AIDS with significant immune system damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance the immune response against HIV and improve treatment outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding viral mechanisms, suggesting that this approach could yield valuable insights into HIV treatment.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Ambrose, Zandrea — University of Pittsburgh at Pittsburgh
- Study coordinator: Ambrose, Zandrea
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.