Understanding how HIV-1 interacts with host cell proteins during infection
Roles of HIV-1 capsid-binding FG-motif containing cellular cofactors in infection
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11009047
This study is looking at how the HIV-1 virus gets into our cells and what proteins help it do that, which could help find new ways to treat HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11009047 on ClinicalTrials.gov |
What this research studies
This research investigates the early stages of HIV-1 infection, focusing on how the virus interacts with specific host cell proteins that facilitate its entry into cells. By studying the capsid protein of HIV-1 and its interactions with cellular cofactors, the research aims to uncover the molecular mechanisms that allow the virus to successfully navigate through the host cell's cytoplasm and nucleus. The approach includes identifying key proteins involved in this process and understanding their roles in viral infection. This could lead to new insights into potential therapeutic targets for HIV treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection.
Not a fit: Patients who are not infected with HIV or do not have risk factors for HIV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new strategies to prevent or treat HIV infection.
How similar studies have performed: Other research has shown success in understanding virus-host interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KVARATSKHELIA, MAMUKA — UNIVERSITY OF COLORADO DENVER
- Study coordinator: KVARATSKHELIA, MAMUKA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.