Understanding how HIV-1 hides in the body and how to target it
Defining the epigenetic landscape at the HIV-1 provirus 3’-end
This study is looking into how HIV-1 can stay hidden in the body even when people are taking their medications, and it hopes to find new ways to help get rid of the virus for good, making treatments better for those living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10850257 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which HIV-1 remains hidden in the body despite treatment with anti-retroviral therapy (ART). It focuses on the role of specific chemical modifications to DNA and histones that may allow the virus to evade detection by the immune system. By studying these modifications, the research aims to develop new strategies to eliminate the persistent HIV-1 reservoirs in patients. This could lead to more effective treatments and potentially a functional cure for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on anti-retroviral therapy but still have detectable viral reservoirs.
Not a fit: Patients who are not living with HIV or those who have not responded to anti-retroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively eliminate HIV-1 from the body, improving the health and quality of life for patients living with HIV.
How similar studies have performed: Previous research has shown promise in targeting HIV-1 reservoirs using similar approaches, indicating potential for success in this area.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: D'orso, Ivan — Ut Southwestern Medical Center
- Study coordinator: D'orso, Ivan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.