Understanding how HIV-1 enters the nucleus of human cells
Delineating HIV-1 nuclear import mechanisms through capsid interaction with MxB and the nuclear pore complex
This study is looking at how the HIV-1 virus gets into the center of human cells, focusing on how it interacts with certain proteins, which could help scientists find new ways to fight the virus and improve treatments for people living with HIV.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10900794 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which HIV-1, a virus that causes lifelong infection, enters the nucleus of human cells. It focuses on the interaction between the virus's capsid proteins and host factors, particularly the myxovirus resistance protein B (MxB) and the nuclear pore complex. By examining these interactions, the research aims to clarify how HIV-1 uncoats and integrates into the host genome, which is crucial for developing new antiviral strategies. The study employs advanced techniques like cryo-electron microscopy to visualize these processes at a molecular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1 who are seeking new treatment options.
Not a fit: Patients who are not infected with HIV-1 or those who have already achieved viral suppression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new antiviral therapies that more effectively target HIV-1 and improve treatment outcomes for patients.
How similar studies have performed: Other research has shown promise in understanding viral entry mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Torres Rivera, Dariana — Emory University
- Study coordinator: Torres Rivera, Dariana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.