Understanding how HIV-1 enters human cells
A multiscale approach for elucidating nuclear entry mechanisms of HIV-1 capsid
This study is looking at how the HIV-1 virus gets into the nucleus of human cells, which is important for it to cause infection, and it's designed for researchers who want to better understand this process and find new ways to stop the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10909419 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the HIV-1 virus gains access to the nucleus of human cells, which is crucial for its infectivity. The team aims to develop innovative in vitro models that mimic the complex structures of nuclear pore complexes, allowing for a better understanding of how the viral capsid interacts with these cellular barriers. By using advanced DNA-origami technology, the researchers will create precise models that replicate the conditions of the nuclear environment, facilitating detailed studies of the viral entry process.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection.
Not a fit: Patients who are not infected with HIV and do not have risk factors for HIV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing HIV-1 infection.
How similar studies have performed: Previous research has shown promise in understanding viral entry mechanisms, but this approach using DNA-origami technology is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Xiong, Yong — Yale University
- Study coordinator: Xiong, Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.