Understanding how HIV-1 enters human cells
Structure of HIV-1 envelope spike in the context of membrane
This study is looking at how the HIV virus connects with our immune cells to enter the body, which could help scientists find better treatments or vaccines for HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10752689 on NIH RePORTER |
What this research studies
This research investigates the structure of the HIV-1 envelope spike, which is crucial for the virus to fuse with and enter human cells. By examining the interactions between the virus and the CD4 receptor on immune cells, the study aims to uncover the detailed mechanisms of membrane fusion. The researchers utilize advanced techniques to visualize the full-length envelope protein in a membrane-like environment, which could reveal important insights into how HIV-1 establishes infection. This knowledge may lead to the development of more effective treatments or vaccines against HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection.
Not a fit: Patients who are not infected with HIV and do not have risk factors for HIV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in HIV treatment and prevention strategies.
How similar studies have performed: Previous studies have shown success in understanding viral entry mechanisms, but this specific approach to studying the full-length HIV-1 envelope in a membrane context is relatively novel.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chen, Bing — Boston Children's Hospital
- Study coordinator: Chen, Bing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.