Understanding how HIV-1 assembles in cells
Mechanisms that determine subcellular sites of HIV-1 assembly
['FUNDING_R37'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11061606
This study is looking at how the HIV-1 virus puts itself together in cells, focusing on a key protein called Gag, to learn more about how it interacts with the cell and could help develop better treatments for people living with HIV.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11061606 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which HIV-1, the virus responsible for AIDS, assembles at specific sites within cells, particularly at the plasma membrane. It focuses on a viral protein called Gag, which plays a crucial role in this assembly process. The study aims to understand how Gag interacts with cellular components, such as lipids and tRNAs, to ensure proper localization and efficient virus release. By examining these interactions, the research seeks to uncover new insights into the viral life cycle that could inform future therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV/AIDS who are seeking innovative treatment options.
Not a fit: Patients who are not infected with HIV or those who have already achieved viral suppression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that inhibit HIV-1 assembly, potentially improving outcomes for patients with HIV/AIDS.
How similar studies have performed: Previous research has shown promising results in understanding viral assembly mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ONO, AKIRA — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: ONO, AKIRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome