Understanding how HIV-1 assembles in cells
Mechanisms that determine subcellular sites of HIV-1 assembly
This study is looking at how the HIV-1 virus puts itself together in cells, focusing on a key protein called Gag, to better understand how it spreads and behaves, which could help in finding new ways to fight the virus.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10873673 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which HIV-1, the virus responsible for AIDS, assembles at the plasma membrane of cells. It focuses on a viral protein called Gag, which plays a crucial role in this assembly process. The study aims to uncover how Gag interacts with specific lipids and tRNAs to determine its localization and assembly efficiency. By examining these interactions, researchers hope to gain insights into the virus's behavior and its spread between cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV/AIDS who are interested in understanding the biological mechanisms of the virus.
Not a fit: Patients who are not infected with HIV or those who have already achieved viral suppression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing HIV-1 infection and improving treatment options for patients with AIDS.
How similar studies have performed: Previous research has shown success in understanding viral assembly mechanisms, but this specific approach is novel and aims to provide deeper insights into HIV-1.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Ono, Akira — University of Michigan at Ann Arbor
- Study coordinator: Ono, Akira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.