Understanding how HIV-1 assembles and spreads in the body
Official title: Identifying determinants of HIV-1 responsible for the nanoscale distribution and dynamics of virus assembly
Funded at University of Denver (Colorado Seminary) · NIH-11124168 · Data updated 2026-11-12
This study is looking at how the HIV-1 virus puts itself together and uses important proteins to spread, using special imaging tools to see how these proteins move and interact, which could help us find new ways to treat HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Denver (Colorado Seminary) NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | May 10, 2018 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $444,776 |
| NIH project number | 5R01AI138625-07 |
| Project ID | NIH-11124168 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV-1 or those at high risk of infection.
✕Less likely to help
Patients who are not infected with HIV-1 and do not have risk factors for infection may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the assembly of HIV-1, focusing on how the virus incorporates essential proteins during its formation. By using advanced imaging techniques, the study aims to visualize the three-dimensional organization and movement of these proteins at a nanoscale level. The project will also explore how host cell factors influence the virus's ability to spread from one cell to another. This comprehensive approach could lead to new insights into HIV-1 behavior and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating HIV-1 infections.
How similar studies have gone: Previous research has shown promise in understanding viral assembly mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Denver (Colorado Seminary)
Denver, United States Active
Researchers
- Principal investigator: Van Engelenburg, Schuyler — University of Denver (Colorado Seminary)
- Study coordinator: Van Engelenburg, Schuyler
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.