Understanding how HIV-1 assembles and how a new drug targets it
Structural interrogation of the HIV-1 virion and the mechanism of the capsid targeting compound Lenacapavir
This study is looking at how the HIV-1 virus puts itself together and grows, and it’s for anyone interested in understanding how a new antiviral medicine called Lenacapavir works to fight the virus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11195813 on NIH RePORTER |
What this research studies
This research investigates the structural details of HIV-1, focusing on how the virus assembles and matures. By using advanced imaging techniques like cryo-electron microscopy, researchers will analyze the viral protein structures involved in the infection process. The goal is to understand how a specific antiviral compound, Lenacapavir, interacts with the virus's capsid, which is crucial for its ability to infect cells. This knowledge could lead to the development of more effective antiviral therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1 who may benefit from new antiviral therapies.
Not a fit: Patients who are not infected with HIV-1 or those who have already exhausted all available antiviral options may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved antiviral treatments for HIV-1, potentially enhancing patient outcomes.
How similar studies have performed: Previous research has shown success in targeting viral structures to develop effective antiviral therapies, indicating a promising approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Dick, Robert a — Emory University
- Study coordinator: Dick, Robert a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.