Understanding how HIV-1 assembles and disassembles during its life cycle
Official title: Assembly and Disassembly Processes in the HIV-1 Life Cycle
Funded at University of Chicago · NIH-10997817 · Data updated 2026-11-12
This study is looking at how the HIV-1 virus puts itself together and breaks apart to spread and make copies of itself, with the hope that understanding these steps can help create new treatments for people living with HIV.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2027 |
| Funding year | 2024 |
| Award (this year) | $73,408 |
| NIH project number | 1F32AI186429-01 |
| Project ID | NIH-10997817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV-1 who may benefit from new therapeutic strategies targeting the virus's life cycle.
✕Less likely to help
Patients who are not infected with HIV-1 or those who have already achieved viral suppression may not receive direct benefits from this research.
What this research studies
This research investigates the processes by which the HIV-1 virus assembles and disassembles to infect new cells and replicate. It focuses on critical transitions in the virus's life cycle, such as the formation of the immature virion and the maturation of the viral core. By using computational methods, the study aims to understand the roles of various factors, including viral RNA and host cell components, in these processes. This knowledge could lead to the development of new antiretroviral therapies that target these specific stages of the virus's life cycle.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for HIV-1, improving health outcomes for patients living with the virus.
How similar studies have gone: Previous research has shown promise in targeting similar processes in viral life cycles, indicating that this approach could yield significant advancements.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Waltmann, Curt — University of Chicago
- Study coordinator: Waltmann, Curt
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.