Understanding how HIV-1 affects inflammation in lymphoid tissues
Probing the Role of Secondary Lymphoid Tissue Architecture in HIV-1 Associated NLRP3 Inflammasome Signaling
This study is looking at how the structure of certain tissues in the body affects inflammation caused by HIV-1, even in people who are taking effective treatment, to help find new ways to reduce this inflammation and improve health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11085518 on NIH RePORTER |
What this research studies
This research investigates the role of lymphoid tissue architecture in the inflammatory response associated with HIV-1 infection. It focuses on how HIV-1 can cause chronic inflammation even when patients are on effective antiretroviral therapy. By using a specialized model that preserves the natural structure of human tonsil tissue, the study aims to identify the immune cells and signaling pathways involved in this inflammatory response. This could lead to the development of targeted therapies that work alongside existing treatments to reduce inflammation and its associated risks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently receiving antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new anti-inflammatory treatments that improve health outcomes for people living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding inflammatory responses in HIV, but this specific approach using lymphoid tissue architecture is relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Mangold, Jesse Francis — Icahn School of Medicine at Mount Sinai
- Study coordinator: Mangold, Jesse Francis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.