Understanding how HIV-1 affects inflammation in lymphoid tissues
Official title: Probing the Role of Secondary Lymphoid Tissue Architecture in HIV-1 Associated NLRP3 Inflammasome Signaling
Funded at Icahn School of Medicine at Mount Sinai · NIH-11085518 · Data updated 2026-11-12
This study is looking at how the structure of certain tissues in the body affects inflammation caused by HIV-1, even in people who are taking effective treatment, to help find new ways to reduce this inflammation and improve health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $49,474 |
| NIH project number | 1F30AI189255-01 |
| Project ID | NIH-11085518 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently receiving antiretroviral therapy.
✕Less likely to help
Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates the role of lymphoid tissue architecture in the inflammatory response associated with HIV-1 infection. It focuses on how HIV-1 can cause chronic inflammation even when patients are on effective antiretroviral therapy. By using a specialized model that preserves the natural structure of human tonsil tissue, the study aims to identify the immune cells and signaling pathways involved in this inflammatory response. This could lead to the development of targeted therapies that work alongside existing treatments to reduce inflammation and its associated risks.
Why it matters
Potential benefit: If successful, this research could lead to new anti-inflammatory treatments that improve health outcomes for people living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding inflammatory responses in HIV, but this specific approach using lymphoid tissue architecture is relatively novel.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Mangold, Jesse Francis — Icahn School of Medicine at Mount Sinai
- Study coordinator: Mangold, Jesse Francis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.