Understanding how histone tails affect gene regulation and chromatin structure
The role of histone tails in chromatin structure and gene regulation
This study is looking at how certain parts of proteins that help organize our DNA can affect how our genes work, which could help us understand and improve treatments for conditions like cancer and metabolic disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11108391 on NIH RePORTER |
What this research studies
This research investigates the role of histone tails, which are parts of proteins that help package DNA into chromatin, in regulating gene expression. By examining how these tails interact with DNA and other proteins, the study aims to uncover the mechanisms that lead to proper or improper gene regulation. The research employs advanced molecular techniques to analyze the structure and dynamics of histone tails, which could provide insights into diseases like cancer and metabolic disorders. Patients may benefit from a better understanding of how gene regulation works and how it can be corrected when it goes awry.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancers or metabolic disorders linked to gene regulation.
Not a fit: Patients with conditions unrelated to chromatin structure or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for correcting gene regulation issues associated with various diseases.
How similar studies have performed: Other research has shown promising results in understanding chromatin regulation and its implications for disease, indicating that this approach has potential for success.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Morrison, Emma Antonina — Medical College of Wisconsin
- Study coordinator: Morrison, Emma Antonina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.