Understanding how histone tails affect gene regulation and chromatin structure
The role of histone tails in chromatin structure and gene regulation
['FUNDING_OTHER'] · MEDICAL COLLEGE OF WISCONSIN · NIH-10849748
This study is looking at how tiny parts of proteins, called histone tails, help control how our genes work, which could help us understand diseases like cancer and diabetes better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-10849748 on ClinicalTrials.gov |
What this research studies
This research investigates the role of histone tails, which are parts of proteins that help package DNA into chromatin, in regulating gene expression. By examining how these tails interact with DNA and other proteins, the research aims to uncover the mechanisms that control gene activity and chromatin structure. The study employs advanced molecular techniques to analyze the dynamics and modifications of histone tails, which could reveal how disruptions in these processes contribute to diseases like cancer and diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or metabolic disorders linked to chromatin dysregulation.
Not a fit: Patients with conditions unrelated to chromatin structure or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for correcting gene regulation issues associated with various diseases.
How similar studies have performed: Previous research has shown promising results in understanding chromatin regulation and its implications for disease, indicating that this approach has potential for success.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MORRISON, EMMA ANTONINA — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: MORRISON, EMMA ANTONINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Cardiac Diseases, Cardiac Disorders