Understanding how histone reader proteins work and their role in diseases.
Official title: Highly parallelized characterization of histone reader dysfunction
Funded at Duke University · NIH-11069096 · Data updated 2026-11-12
This study is looking at how certain proteins help control the way our DNA works, which could lead to new treatments for diseases related to DNA changes, and it uses advanced technology to understand these interactions better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $75,052 |
| NIH project number | 1F32GM157893-01 |
| Project ID | NIH-11069096 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations affecting histone reader proteins or related chromatin regulation disorders.
✕Less likely to help
Patients without any known chromatin regulation disorders or those not carrying relevant genetic mutations may not benefit from this research.
What this research studies
This research investigates the role of histone reader proteins in regulating chromatin, which is crucial for DNA function. By developing a new high-throughput platform, the study aims to analyze how these proteins interact with modified histones, particularly focusing on mutations that may affect their function. Patients may benefit from insights gained about the mechanisms behind various diseases linked to chromatin regulation, potentially leading to new therapeutic targets. The research employs advanced robotics and assays to systematically explore these interactions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases associated with chromatin regulation errors.
How similar studies have gone: Previous research has shown promise in understanding chromatin regulation, but this approach using ultra-high-throughput methods is relatively novel.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Boileau, Ryan Michael — Duke University
- Study coordinator: Boileau, Ryan Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.