Understanding how histone proteins help compact DNA in cells
Official title: Molecular mechanisms of the core and linker histone tail domains that drive chromatin condensation
Funded at University of Rochester · NIH-11051844 · Data updated 2026-11-12
This study is looking at how certain parts of histone proteins help DNA get organized in our cells, which is important for keeping our genes working properly, and it aims to learn more about how changes to these proteins can affect that organization.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | April 10, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $346,500 |
| NIH project number | 5R35GM149420-03 |
| Project ID | NIH-11051844 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions linked to chromatin structure and function, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with conditions unrelated to chromatin dynamics or those who do not have a genetic basis for their disease may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms by which histone proteins, specifically their tail domains, contribute to the condensation of chromatin, the complex that packages DNA within the cell nucleus. By using biochemical and biophysical techniques, the study aims to uncover how these histone tails interact with each other and how modifications like acetylation affect these interactions. This understanding could provide insights into gene regulation and cellular processes that are crucial for maintaining proper cell function. The research will utilize model systems to explore these interactions in detail.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression and improving treatments for diseases related to chromatin dysfunction.
How similar studies have gone: Other research has shown promising results in understanding chromatin dynamics and its implications for gene regulation, indicating that this approach is building on established findings.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Hayes, Jeffrey J — University of Rochester
- Study coordinator: Hayes, Jeffrey J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.