Understanding how histone proteins help compact DNA in cells
Molecular mechanisms of the core and linker histone tail domains that drive chromatin condensation
['FUNDING_OTHER'] · UNIVERSITY OF ROCHESTER · NIH-11051844
This study is looking at how certain parts of histone proteins help DNA get organized in our cells, which is important for keeping our genes working properly, and it aims to learn more about how changes to these proteins can affect that organization.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11051844 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms by which histone proteins, specifically their tail domains, contribute to the condensation of chromatin, the complex that packages DNA within the cell nucleus. By using biochemical and biophysical techniques, the study aims to uncover how these histone tails interact with each other and how modifications like acetylation affect these interactions. This understanding could provide insights into gene regulation and cellular processes that are crucial for maintaining proper cell function. The research will utilize model systems to explore these interactions in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to chromatin structure and function, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to chromatin dynamics or those who do not have a genetic basis for their disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression and improving treatments for diseases related to chromatin dysfunction.
How similar studies have performed: Other research has shown promising results in understanding chromatin dynamics and its implications for gene regulation, indicating that this approach is building on established findings.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAYES, JEFFREY J — UNIVERSITY OF ROCHESTER
- Study coordinator: HAYES, JEFFREY J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.