Understanding how histone mRNAs are regulated during cell development
Official title: Histone mRNA Regulation in Development
Funded at Univ of North Carolina Chapel Hill · NIH-11187394 · Data updated 2026-11-12
This study is looking at how certain important molecules called histone mRNAs are made in a special part of the cell during its growth phase, which could help us understand how cells divide and develop properly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | September 9, 2024 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $260,243 |
| NIH project number | 3R01GM058921-24S1 |
| Project ID | NIH-11187394 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to abnormal cell growth or proliferation, such as certain types of cancer.
✕Less likely to help
Patients with non-cancerous conditions or those not affected by issues related to cell cycle regulation may not benefit from this research.
What this research studies
This research investigates the unique regulation of histone mRNAs, which are crucial for cell division and development. It focuses on how these mRNAs are synthesized in a specialized nuclear structure called the histone locus body (HLB) and how this process is activated during the S-phase of the cell cycle. By examining the assembly and activation of the factors involved in histone mRNA biosynthesis, the research aims to uncover the mechanisms that control gene expression in developing cells. This could provide insights into cellular processes that are fundamental to growth and development.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cell growth and division, potentially informing treatments for cancers and other growth-related disorders.
How similar studies have gone: Other research has shown promising results in understanding gene regulation mechanisms, making this approach both relevant and potentially impactful.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Marzluff, William F. — Univ of North Carolina Chapel Hill
- Study coordinator: Marzluff, William F.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.