Understanding how histone modifications affect gene expression during cell division
Control of histone ubiquitylation during the cell cycle
This study is looking at how certain chemical changes to proteins in our cells can affect how genes work during the cell cycle, which could help us understand diseases like neurodegeneration and aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10916241 on NIH RePORTER |
What this research studies
This research investigates the role of histone ubiquitylation, a chemical modification of proteins, in regulating gene expression during the cell cycle. By examining how specific enzymes remove these modifications from histones, the study aims to uncover the mechanisms that control gene activity and cellular function. The research will involve detailed biochemical analyses and genetic experiments to identify the enzymes involved and their specific targets in the genome. This could provide insights into how misregulation of these processes may lead to diseases such as neurodegeneration and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to neurodegenerative diseases or age-related disorders.
Not a fit: Patients with conditions unrelated to gene regulation or those not experiencing age-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to gene regulation errors, such as neurodegenerative disorders and age-related conditions.
How similar studies have performed: Previous research has shown promising results in understanding histone modifications and their impact on gene expression, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Oh, Eugene — Massachusetts General Hospital
- Study coordinator: Oh, Eugene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.