Understanding how histone modifications affect DNA replication and cell identity
Histone Acetylation Dynamics and Epigenome Duplication
This study looks at how the structure of our genes and special proteins called histones work together to control how our genes are expressed and kept stable, helping us understand how traits are passed down through generations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11010006 on NIH RePORTER |
What this research studies
This research investigates the complex 3-dimensional structure of eukaryotic genomes and how histone proteins influence gene expression and genome stability. It focuses on the mechanisms of epigenetic inheritance, specifically how histone modification patterns are passed on during DNA replication and cell division. By examining the interactions between parental and newly synthesized histones, the research aims to uncover fundamental processes that regulate chromatin states and maintain cell identity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to chromatin structure and gene expression, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to chromatin dynamics or histone modifications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how gene expression is regulated, potentially impacting treatments for diseases related to gene dysregulation.
How similar studies have performed: Previous research has shown promising results in understanding histone modifications and their role in gene regulation, suggesting that this approach has potential for significant findings.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Parthun, Mark R — Ohio State University
- Study coordinator: Parthun, Mark R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.