Understanding how histone modifications affect cell differentiation
Control of histone methylation during differentiation
This study looks at how certain changes in cell structure can affect how cells develop and function, using yeast as a model, and aims to help us understand how mistakes in these processes might lead to cancer and other health issues.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Richard Stockton College of New Jersey NIH-funded |
| Lab location | 1 site (Galloway, United States) |
| Project ID | NIH-10201923 on NIH RePORTER |
What this research studies
This research investigates the role of histone methylation in the differentiation of cells, particularly focusing on how these modifications influence gene expression during the development of certain cell types. By studying the budding yeast S. cerevisiae, the researchers aim to uncover the mechanisms that regulate the COMPASS complex, which is crucial for histone modification. The project will explore how changes in this complex affect the process of meiosis, which is essential for reproduction. Patients may benefit from insights gained about how errors in these processes can lead to cancers and developmental defects.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with a family history of cancers or developmental disorders related to cell differentiation.
Not a fit: Patients with conditions unrelated to cell differentiation or histone modification may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers linked to differentiation errors.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown that understanding histone modifications can lead to significant advancements in cancer treatment.
Where this research is happening
Galloway, United States
- Richard Stockton College of New Jersey — Galloway, United States (Active)
Researchers
- Principal investigator: Law, Michael J — Richard Stockton College of New Jersey
- Study coordinator: Law, Michael J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.