Understanding how histone modifications affect aging and cancer
Histone Deacetylation Signaling in Aging and Cancer Pathways
['FUNDING_R01'] · PALO ALTO VETERANS INSTIT FOR RESEARCH · NIH-10866553
This study is looking at how a specific enzyme called SIRT7 affects our genes and how this might relate to aging and cancer, with the hope of finding new ways to help people stay healthier as they get older.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PALO ALTO VETERANS INSTIT FOR RESEARCH (nih funded) |
| Locations | 1 site (PALO ALTO, UNITED STATES) |
| Trial ID | NIH-10866553 on ClinicalTrials.gov |
What this research studies
This research investigates the role of histone deacetylation in regulating chromatin and its implications for aging and cancer. By studying the enzyme SIRT7, the project aims to uncover how changes in histone modifications can lead to genomic instability and age-related diseases. The research utilizes animal models to explore the effects of SIRT7 on lifespan and cellular health, providing insights into potential therapeutic targets for age-associated conditions and cancer. Patients may benefit from findings that could lead to new treatments or preventive strategies for aging-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include older adults or individuals at risk for age-related diseases and cancers.
Not a fit: Patients with acute conditions unrelated to aging or cancer may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating age-related diseases and certain cancers.
How similar studies have performed: Other research has shown promising results in understanding the role of histone modifications in aging and cancer, suggesting that this approach has potential for significant breakthroughs.
Where this research is happening
PALO ALTO, UNITED STATES
- PALO ALTO VETERANS INSTIT FOR RESEARCH — PALO ALTO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHUA, KATRIN F — PALO ALTO VETERANS INSTIT FOR RESEARCH
- Study coordinator: CHUA, KATRIN F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology, Cancer Cause, Cancer Etiology, Cancer cell line, Cancers