Understanding how histone gene regulation works in fruit flies
Official title: Investigating Mechanisms of D. melanogaster Histone Locus Body (HLB) Initiation and Maintenance
Funded at Emory University · NIH-11164080 · Data updated 2026-11-12
This study is looking at how certain structures in fruit flies help control the genes that make histones, which are important for cell growth and development, to better understand how cells divide and develop, with hopes that this knowledge could help in future medical treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 1F31HD118798-01 |
| Project ID | NIH-11164080 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would be individuals interested in advancements in regenerative medicine and stem cell therapies.
✕Less likely to help
Patients with conditions unrelated to gene regulation or developmental biology may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms behind the initiation and maintenance of histone locus bodies (HLBs) in Drosophila, a model organism. By studying how these HLBs regulate histone gene expression during early development, the research aims to uncover critical processes that ensure proper cell division and differentiation. The approach involves manipulating genetic factors in fruit flies to observe the effects on histone gene regulation, which is essential for understanding developmental biology and potential applications in regenerative medicine.
Why it matters
Potential benefit: If successful, this research could lead to advancements in regenerative medicine and stem cell therapies by providing insights into gene regulation during cell differentiation.
How similar studies have gone: While this research explores a well-established area of gene regulation, the specific focus on histone locus bodies in Drosophila is a novel approach that has not been extensively tested.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Roos, Nicole Sunalee — Emory University
- Study coordinator: Roos, Nicole Sunalee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.