Understanding how histone decrotonylation affects HIV latency
Official title: Histone decrotonylation uniquely regulates HIV latency
Funded at Univ of North Carolina Chapel Hill · NIH-11111393 · Data updated 2026-11-12
This study is looking into how certain changes in our cells can keep HIV hidden and help find new ways to wake up the virus so that better treatments can be developed for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | June 10, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $733,530 |
| NIH project number | 5R01AI186609-02 |
| Project ID | NIH-11111393 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who have stable viral loads and are currently on antiretroviral therapy.
✕Less likely to help
Patients who are not living with HIV or those who have advanced AIDS with significant immune compromise may not benefit from this research.
What this research studies
This research investigates the mechanisms behind HIV latency, which is a significant barrier to curing HIV. It focuses on the role of histone modifications, particularly decrotonylation, in regulating the transcription of the HIV virus. By exploring how these epigenetic changes influence HIV reservoirs, the research aims to develop new strategies for activating latent HIV and improving treatment outcomes for individuals living with HIV. The study employs biochemical techniques to analyze the interactions between histones and HIV genetic material.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively target and eliminate latent HIV reservoirs, improving the health and quality of life for people living with HIV.
How similar studies have gone: Previous research has shown promise in targeting HIV latency through epigenetic modifications, suggesting that this approach could lead to significant advancements in HIV treatment.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Jiang, Guochun — Univ of North Carolina Chapel Hill
- Study coordinator: Jiang, Guochun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.