Understanding how Hippo-Yap1 signaling affects early embryo development
The Role of Hippo-Yap1 Signaling in Germ-layer Specification
This study is looking at how a specific signaling process in early embryo development helps form the three main layers of cells, using human stem cells to see how problems in this process might lead to birth defects, and it could help us understand some developmental disorders better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10845308 on NIH RePORTER |
What this research studies
This research investigates the role of Hippo-Yap1 signaling in the early stages of embryo development, specifically focusing on how it influences the formation of the three germ layers. By utilizing human embryonic stem cells, the researchers aim to understand how disruptions in this signaling pathway can lead to improper cell differentiation and potential birth defects. The study employs advanced techniques, including CRISPR, to manipulate genes and observe their effects on cell fate determination during embryogenesis. The findings could provide insights into the mechanisms behind certain developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are expectant parents concerned about the risk of birth defects or those with a family history of developmental disorders.
Not a fit: Patients who are not pregnant or do not have a family history of birth defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing and treating birth defects.
How similar studies have performed: Other research has shown promising results in understanding signaling pathways related to embryonic development, indicating that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Estaras, Concepcion — Temple Univ of the Commonwealth
- Study coordinator: Estaras, Concepcion
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.