Understanding how Hippo signaling affects pancreas development and insulin-producing cells
Hippo suppression of NFkB controls pancreas morphogenesis and beta cell fate
This study is looking at how a specific signaling pathway in the body affects the growth of the pancreas and the creation of insulin-producing cells, which are important for treating diabetes, and it aims to find better ways to produce these cells for therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10665660 on NIH RePORTER |
What this research studies
This research investigates the role of the Hippo signaling pathway in the development of the pancreas and the generation of insulin-producing beta cells, which are crucial for diabetes treatment. By using advanced techniques such as transgenic mouse models and pancreatic organoids, the study aims to uncover how Hippo signaling influences the specification and differentiation of pancreatic progenitor cells. The researchers will also explore the interactions between Hippo signaling and other pathways, such as NFκB, to better understand the mechanisms that regulate pancreas morphogenesis. This could lead to improved methods for generating functional beta cells for diabetes therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with pre-existing diabetes or those at risk of developing diabetes.
Not a fit: Patients with diabetes types that do not involve issues with beta cell generation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for generating insulin-producing beta cells, offering hope for more effective diabetes treatments.
How similar studies have performed: Previous research has shown promising results in understanding the role of signaling pathways in cell differentiation, suggesting that this approach may yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Cleaver, Ondine B — Ut Southwestern Medical Center
- Study coordinator: Cleaver, Ondine B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.