Understanding how hind limb ischemia protects the heart
Remote Hind Limb Ischemia Mechanism of Cardioprotection
This study is looking at how a special treatment involving your legs can help protect your heart during heart attacks, and it aims to find out how certain helpful substances released from your muscles can improve heart health and support recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-10215605 on NIH RePORTER |
What this research studies
This research investigates the protective effects of remote hind limb ischemia on heart health, particularly during events like myocardial infarction. It aims to uncover the mechanisms behind this protection, focusing on the role of beneficial substances released from skeletal muscle during ischemic episodes. The study will explore how these substances, including exosomes and hydrogen sulfide, can improve heart function and mobilize stem cells to aid recovery. Patients may be involved in understanding how these processes can be harnessed for better heart health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of myocardial infarction or diabetes who may benefit from improved heart protection strategies.
Not a fit: Patients without cardiovascular issues or those not experiencing ischemic events may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart recovery and function after injury.
How similar studies have performed: Previous research has shown promising results in using remote ischemic conditioning for cardioprotection, suggesting that this approach may be effective.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Tyagi, Suresh C. — University of Louisville
- Study coordinator: Tyagi, Suresh C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.