Understanding how high mechanical stress affects immune cells in heart and lung support devices
High Mechanical Shear Stress-Induced Neutrophil Dysfunction in Mechanically Assisted Circulation
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10991696
This study is looking at how the strong forces from heart support devices, like VADs and ECMO, might affect the immune system of patients, especially how it could make them more prone to infections, so we can find ways to keep them safer and healthier.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10991696 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of high mechanical shear stress on neutrophil function in patients using mechanical circulatory support devices like ventricular assist devices (VADs) and extracorporeal membrane oxygenation (ECMO). The study aims to uncover how the mechanical forces from these devices can impair immune cells, potentially leading to increased infections in patients. By analyzing blood samples and immune responses, the research seeks to identify the mechanisms behind this dysfunction and improve patient outcomes. The findings could help enhance the safety and effectiveness of these life-saving technologies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing treatment with mechanical circulatory support devices for advanced heart or respiratory failure.
Not a fit: Patients who are not using mechanical circulatory support devices or those with non-cardiac related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing infections in patients using mechanical heart and lung support devices.
How similar studies have performed: Previous research has shown that understanding the immune response in patients with mechanical support can lead to better management of complications, indicating potential for success in this area.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, ZHONGJUN JON — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: WU, ZHONGJUN JON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.