Understanding how hidden gene changes increase lung cancer risk
Defining signatures of epigenetic sensitization to lung cancer in a mouse model
['FUNDING_R21'] · YALE UNIVERSITY · NIH-11135607
This project explores how subtle changes in gene regulation, called epigenetics, might make some people more likely to develop lung cancer.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11135607 on ClinicalTrials.gov |
What this research studies
We are exploring how early changes in gene regulation, known as epigenetic perturbations, might contribute to the development of lung cancer. Using a special mouse model, we can observe these epigenetic changes before tumors even begin to form, helping us understand their role in cancer risk. Our goal is to identify specific epigenetic patterns in lung tissue that predict a higher chance of developing lung cancer when combined with genetic mutations. This work aims to uncover distinct epigenetic and genetic characteristics within these tumors.
Who could benefit from this research
Good fit: Patients with a family history of lung cancer or those with known genetic risk factors might eventually benefit from the insights gained from this research.
Not a fit: Patients whose lung cancer is not linked to these specific epigenetic or genetic pathways may not directly benefit from this particular line of research.
Why it matters
Potential benefit: If successful, this work could help identify individuals at higher risk for lung cancer and lead to new ways to classify tumors and develop more targeted treatments.
How similar studies have performed: While the specific approach of studying paternal germline epigenetic changes in relation to lung cancer risk is novel, the broader field of epigenetics in cancer is a well-established area of research.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LESCH, BLUMA J — YALE UNIVERSITY
- Study coordinator: LESCH, BLUMA J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Patient, Cancer Treatment, Cancers