Understanding how hidden DNA elements control genes in our bodies
Transcriptional regulation of domesticated transposable elements-derived promoters in human genome
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-11139544
This project looks at how special DNA segments, called transposable elements, help turn genes on and off in different human tissues and cells.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11139544 on ClinicalTrials.gov |
What this research studies
Our bodies contain many hidden DNA segments called transposable elements, which make up about half of our genetic material. While often thought of as "junk DNA," some of these elements can act like switches, turning other genes on or off. This work explores how these switches operate in various human tissues and cell types. We want to understand which genes are controlled by these elements and how they create unique gene activity patterns throughout the body.
Who could benefit from this research
Good fit: This foundational genetic work does not involve direct patient participation, but future studies building on this knowledge may seek individuals with specific genetic conditions.
Not a fit: Patients seeking immediate treatment options or direct clinical interventions would not find direct benefit from this basic science project.
Why it matters
Potential benefit: Understanding how these DNA elements regulate genes could help us learn more about human development and diseases where gene regulation goes wrong.
How similar studies have performed: While the specific role of domesticated TEs as promoters in the human genome is not fully characterized, related work in mice has shown that similar elements can regulate tissue-specific gene expression.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, BO ABER — WASHINGTON UNIVERSITY
- Study coordinator: ZHANG, BO ABER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.