Understanding how HGFL affects kidney problems in sickle cell disease
The role of HGFL in the sickle cell disease nephropathy
This study is looking at how a substance called HGFL affects kidney problems in people with sickle cell disease, with the goal of finding new ways to spot early signs of kidney damage and better understand how sickle cell can lead to long-term kidney issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Howard University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10465036 on NIH RePORTER |
What this research studies
This research investigates the role of HGFL in kidney complications associated with sickle cell disease (SCD). It aims to identify new biomarkers and develop diagnostic tools to detect early signs of kidney damage in SCD patients. By focusing on the mechanisms of kidney injury, particularly podocyte injury, the study seeks to improve understanding of how SCD leads to chronic kidney disease. The approach includes analyzing the relationship between HGFL and renal function in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with sickle cell disease, particularly those experiencing kidney-related issues.
Not a fit: Patients without sickle cell disease or those with advanced chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better treatment options for kidney complications in sickle cell disease patients.
How similar studies have performed: While research on kidney complications in sickle cell disease is ongoing, this specific investigation into HGFL's role is relatively novel and untested.
Where this research is happening
Washington, United States
- Howard University — Washington, United States (Active)
Researchers
- Principal investigator: Jerebtsova, Marina a — Howard University
- Study coordinator: Jerebtsova, Marina a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.