Understanding how herpesviruses invade the nervous system
Virus-host interactions governing alpha-herpesvirus genome delivery and neuroinvasion
This study is looking at how certain herpes viruses can move from nerve cells to important parts of the body like the eye and brain, with the goal of finding ways to prevent and treat these infections better, especially for people who might be at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10763863 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which neuroinvasive herpesviruses, such as herpes simplex virus type 1 and pseudorabies virus, spread from sensory neurons to critical areas like the eye and brain. The study aims to uncover how these viruses bypass the body's defenses to establish lifelong infections in the nervous system. By analyzing virus-host interactions, the researchers hope to identify potential vaccine candidates and develop recombinant viruses that lack neuroinvasive properties. This work could lead to significant advancements in preventing and treating infections caused by these viruses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for herpesvirus infections, particularly those with compromised immune systems or neurological conditions.
Not a fit: Patients who are not affected by herpesvirus infections or do not have related neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new vaccines and therapies that prevent serious infections caused by herpesviruses.
How similar studies have performed: Previous research has shown promise in understanding virus-host interactions, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Smith, Gregory Allan — Northwestern University at Chicago
- Study coordinator: Smith, Gregory Allan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.