Understanding how herpes viruses spread in nerve cells
Molecular and cellular mechanisms of HSV-1 assembly and egress
This study is looking at how the Herpes Simplex Virus 1 (HSV-1) puts itself together and leaves nerve cells, which could help us understand why some people have repeated outbreaks or more serious issues, and it's aimed at finding ways to stop these problems for anyone affected by the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10997342 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the Herpes Simplex Virus 1 (HSV-1) assembles and exits from nerve cells. It focuses on how the virus interacts with specialized neuronal cell biology, particularly in sensory and autonomic neurons of the Peripheral Nervous System. The study aims to identify viral factors that influence the transport and release of the virus, which could lead to recurrent infections and complications such as viral encephalitis. By using advanced techniques to manipulate cellular factors, the research seeks to uncover critical pathways involved in the virus's lifecycle.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with recurrent HSV-1 infections or those experiencing complications related to the virus.
Not a fit: Patients who do not have HSV-1 infections or related neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for HSV-1 infections and related neurological complications.
How similar studies have performed: Previous research has shown success in understanding viral mechanisms in other contexts, suggesting potential for breakthroughs in this area as well.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Hogue, Ian B — Arizona State University-Tempe Campus
- Study coordinator: Hogue, Ian B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.