Understanding how herpes viruses enter cells and cause infections
Mechanism of Herpes Simplex Virus (HSV) Induced Membrane Fusion
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10746833
This study is looking at how the herpes simplex virus (HSV) gets into human cells, which is important for understanding how it can cause serious health issues, and it's aimed at helping people who are affected by this virus.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10746833 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which herpes simplex virus (HSV) induces membrane fusion, a critical step for the virus to enter human cells. By studying HSV-1, the researchers aim to uncover the processes that allow the virus to infect cells and potentially lead to serious conditions like cancer and encephalitis. The approach involves using cell cultures to observe how the virus interacts with cell membranes, which could provide insights into preventing infections and improving treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of herpesvirus infections, particularly those who are also dealing with cancer or immunocompromised conditions.
Not a fit: Patients who do not have herpesvirus infections or related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for herpesvirus-related diseases, particularly in cancer patients who are at higher risk.
How similar studies have performed: Previous research has shown success in understanding viral entry mechanisms, making this approach promising for further advancements in herpesvirus treatment.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LONGNECKER, RICHARD M — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: LONGNECKER, RICHARD M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer