Understanding how herpes simplex virus packages its DNA
Structure and function of the portal vertex on the herpes simplex virus capsid
This study is looking at how the herpes simplex virus packs its DNA into its protective shell, using special imaging techniques to better understand the virus's structure and function, which could help develop new treatments for those affected by the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11058387 on NIH RePORTER |
What this research studies
This research investigates the structure and function of the portal vertex of the herpes simplex virus, focusing on how the virus packages its DNA into capsids. By utilizing advanced cryo-electron microscopy techniques, the researchers aim to visualize the interactions between viral proteins and the DNA packaging machinery. This work combines expertise in virology and structural biology to uncover critical details about the herpesvirus lifecycle, which could lead to new therapeutic strategies. The research involves analyzing the roles of specific viral genes and proteins in the packaging process.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with herpes simplex virus infections, particularly those experiencing recurrent outbreaks.
Not a fit: Patients who do not have herpes simplex virus infections are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for herpes simplex virus infections.
How similar studies have performed: Other research has shown success in using cryo-electron microscopy to study viral structures, indicating that this approach is promising.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Conway, James F. — University of Pittsburgh at Pittsburgh
- Study coordinator: Conway, James F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.