Understanding how herpes simplex virus enters human cells
Official title: Membrane sphingomyelin and HSV entry
Funded at Washington State University · NIH-10991034 · Data updated 2026-11-12
This study is looking at how the herpes simplex virus gets into human cells and how a part of our cell membranes, called sphingomyelin, helps with that process, which could lead to better ways to prevent infections for people with HSV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project start | November 21, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $185,513 |
| NIH project number | 5R21AI176338-02 |
| Project ID | NIH-10991034 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of herpes simplex virus infections, including those with a history of cold sores or genital herpes.
✕Less likely to help
Patients who are not at risk for herpes simplex virus infections or those who have already been effectively treated may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the herpes simplex virus (HSV) enters human cells, focusing on the role of sphingomyelin, a key component of cell membranes. The project aims to uncover how HSV interacts with host cell membranes during the entry process, which is crucial for the virus's ability to cause infections. By employing various assays, the researchers will analyze different stages of viral entry, including how the virus attaches to cells and how it is transported within the cell. This work could lead to new insights into preventing HSV infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating herpes simplex virus infections, potentially reducing the incidence of related diseases such as cold sores and blindness.
How similar studies have gone: Previous research has shown that understanding viral entry mechanisms can lead to significant advancements in treatment strategies, indicating that this approach has potential for success.
Where this research is happening
-
Washington State University
Pullman, United States Active
Researchers
- Principal investigator: Nicola, Anthony V — Washington State University
- Study coordinator: Nicola, Anthony V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.