Understanding how herpes simplex virus causes severe eye and brain infections
Viral determinants in HSV virulence
['FUNDING_R01'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10831383
This study is looking at how the herpes simplex virus causes infections that can lead to serious eye problems and brain inflammation, with the goal of finding better ways to treat or prevent these issues for people living with HSV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10831383 on ClinicalTrials.gov |
What this research studies
This research investigates the herpes simplex virus (HSV), which is a leading cause of infectious blindness and viral encephalitis. The study focuses on how HSV infects epithelial cells and spreads to sensory neurons, establishing a lifelong latency that can lead to recurrent infections. By examining the virus's interaction with the immune system and its ability to evade host defenses, the research aims to uncover the mechanisms behind HSV's virulence and inflammation. This could lead to new insights into potential treatments or preventive measures for those affected by HSV.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of herpes simplex virus infections, particularly those experiencing recurrent episodes or complications such as eye infections.
Not a fit: Patients who have never been infected with herpes simplex virus or those with unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments or preventive strategies for patients suffering from HSV-related diseases.
How similar studies have performed: Previous research has shown success in understanding viral mechanisms in other infections, suggesting that this approach may yield valuable insights into HSV as well.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HE, BIN — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: HE, BIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.