Understanding how HER receptors control cell growth and survival
Structural and Functional Studies of HER Receptors
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10986110
This study is looking at how certain proteins called HER receptors help cells grow and stay alive, which is important for understanding cancer better and finding new treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10986110 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which HER receptors, a type of receptor tyrosine kinase, regulate cellular growth and survival. It aims to uncover the structural details of these receptors, particularly how they form dimers and activate their kinase domains, which is crucial for signal transduction. By using advanced techniques like cryo-electron microscopy, the study seeks to provide high-resolution images of the full-length HER receptors. This knowledge could lead to better understanding of cancer biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that involve HER receptor signaling, such as breast or lung cancer.
Not a fit: Patients with cancers unrelated to HER receptor signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting HER receptors in cancer treatment.
How similar studies have performed: Previous research has shown success in understanding receptor tyrosine kinases, but this specific approach to studying HER receptors is novel.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JURA, NATALIA — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: JURA, NATALIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers