Understanding how hepatitis C virus affects the immune system using animal models
Official title: Animal Model to study heterogeneous outcomes of HCV Infection and Pathogenesis
Funded at Research Inst Nationwide Children's Hosp · NIH-11097321 · Data updated 2026-11-12
This study is looking at why some people with hepatitis C clear the virus while others end up with a long-lasting infection, using special animal models to learn more about how the immune system works in these different situations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $780,961 |
| NIH project number | 5R01AI183877-02 |
| Project ID | NIH-11097321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals infected with hepatitis C virus, particularly those who have developed chronic infections.
✕Less likely to help
Patients who have successfully cleared the hepatitis C virus or those without any history of HCV infection may not benefit from this research.
What this research studies
This research investigates the different outcomes of hepatitis C virus (HCV) infections, focusing on why some individuals clear the virus while others develop chronic infections. By using specially adapted animal models, researchers aim to study the immune responses involved in these varying outcomes. The study involves isolating and adapting a rodent HCV-like virus to better understand the mechanisms of viral persistence and clearance. This approach will help identify the viral and immune factors that contribute to chronic infection and potential liver damage.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and strategies for managing hepatitis C infections and preventing chronic disease.
How similar studies have gone: Previous research using animal models to study viral infections has shown promise, indicating that this approach could yield valuable insights into HCV pathogenesis.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Kapoor, Amit — Research Inst Nationwide Children's Hosp
- Study coordinator: Kapoor, Amit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.