Understanding How Hepatitis B Virus Persists
Molecular Mechanisms of HBV cccDNA Formation
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11122232
This research explores how the Hepatitis B virus creates a special form of DNA that helps it hide in the body and makes it hard to cure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11122232 on ClinicalTrials.gov |
What this research studies
This research aims to understand the exact steps the Hepatitis B virus takes to establish a long-lasting infection. We know that a specific type of viral DNA, called cccDNA, is key to the virus staying in your body and causing it to return even after treatment. This project focuses on how the virus converts its initial genetic material into this persistent cccDNA form, using the body's own repair systems. By uncovering these detailed processes, we hope to find new ways to stop the virus from hiding and make current treatments more effective.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit anyone living with chronic Hepatitis B infection.
Not a fit: Patients without Hepatitis B infection would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new medications that directly target the virus's ability to persist, offering a path towards a complete cure for Hepatitis B.
How similar studies have performed: While the role of cccDNA in HBV persistence is well-known, this research delves into novel molecular details of its formation, building upon existing knowledge but exploring new mechanisms.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUO, HAITAO — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: GUO, HAITAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.