Understanding how hepatitis B virus causes cancer
Unveiling a Novel Mechanism of Oncovirus-Induced Carcinogenesis
This study looks at how the hepatitis B virus might cause liver cancer by examining tumors and cells from patients with the virus, hoping to find ways to better understand and treat those affected by HBV-related cancers.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11040102 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the hepatitis B virus (HBV) contributes to cancer development, particularly liver cancer. By analyzing HBV-positive tumors and cell lines, the researchers aim to identify how HBV integrates into the host genome and potentially alters gene expression. The study employs advanced sequencing techniques to map these integrations and explore their role in chromosomal translocations that may lead to cancer. Patients with HBV-related cancers may benefit from insights gained through this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with HBV-related liver cancer or those chronically infected with hepatitis B.
Not a fit: Patients without hepatitis B virus infection or those with cancers unrelated to viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating liver cancer associated with hepatitis B virus.
How similar studies have performed: Previous research has shown that understanding viral mechanisms in cancer can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Cao, Jian — Rutgers Biomedical and Health Sciences
- Study coordinator: Cao, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.