Understanding how hepatitis B virus behaves to improve treatments
Collaborative Integration of Hepatitis B Molecular Virology and Mathematical/Computational Modeling
This study is looking at how the hepatitis B virus works in the body to help create better treatments for people living with the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project ID | NIH-10542358 on NIH RePORTER |
What this research studies
This research investigates the dynamics of hepatitis B virus (HBV) infection at the molecular level to develop more effective treatments. By using advanced mouse models with humanized livers and cell cultures, researchers aim to understand how HBV infects cells and how current antiviral drugs work. The study employs mathematical and computational modeling to analyze infection patterns and treatment responses, which could lead to identifying new antiviral targets and improving existing therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are chronically infected with hepatitis B virus and have not responded adequately to current antiviral therapies.
Not a fit: Patients who are not infected with hepatitis B virus or those who have already achieved a complete cure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for hepatitis B, potentially curing more patients.
How similar studies have performed: Previous research has shown promise in using mathematical modeling and humanized mouse models to study viral infections, indicating that this approach could yield valuable insights.
Where this research is happening
Maywood, United States
- Loyola University Chicago — Maywood, United States (Active)
Researchers
- Principal investigator: Uprichard, Susan L. — Loyola University Chicago
- Study coordinator: Uprichard, Susan L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.