Understanding how hepatitis B virus behaves in people with and without HIV
Mechanisms of HBV cccDNA transcriptional regulation in persons with and without HIV
This study is looking at how the hepatitis B virus works in people who have both hepatitis B and HIV, with the hope of finding new ways to treat and possibly cure hepatitis B for those who are affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10882261 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the hepatitis B virus (HBV) regulates its genetic material in individuals, particularly focusing on those who are co-infected with HIV. The study employs advanced techniques such as single-cell laser capture microdissection and droplet digital PCR to analyze liver tissues from patients. By comparing the behavior of HBV in individuals with only hepatitis B versus those with both hepatitis B and HIV, the research aims to uncover potential therapeutic targets that could lead to a functional cure for HBV. The ultimate goal is to improve treatment outcomes for patients suffering from chronic hepatitis B and its complications.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are chronically infected with hepatitis B, particularly those who may also be co-infected with HIV.
Not a fit: Patients who do not have hepatitis B or HIV may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively eliminate hepatitis B virus from the body, significantly improving health outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding viral behavior in similar contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Balagopal, Ashwin — Johns Hopkins University
- Study coordinator: Balagopal, Ashwin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.