Understanding how hepatitis B virus affects HIV co-infection and immune responses
Official title: Quantifying the frequency and diversity of spliced HBV mRNAs in HIV-HBV co-infection and their role in modulating viral transcription and host immune responses
Funded at Johns Hopkins University · NIH-10896950 · Data updated 2026-11-12
This study is looking at how the hepatitis B virus and HIV work together in people who have both infections, to better understand how certain parts of the hepatitis virus might affect treatment and the immune system, with the goal of finding better ways to help those patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AI179435-02 |
| Project ID | NIH-10896950 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with both HIV and chronic hepatitis B virus infection.
✕Less likely to help
Patients who are solely infected with HIV or hepatitis B without co-infection may not benefit from this research.
What this research studies
This research investigates the interaction between hepatitis B virus (HBV) and HIV in individuals co-infected with both viruses. It focuses on the frequency and diversity of spliced HBV mRNAs and their potential role in influencing viral replication and the body's immune response. By analyzing how these spliced mRNAs behave in patients, the research aims to uncover mechanisms that could lead to improved treatment strategies. The study employs advanced molecular techniques to quantify HBV mRNA and assess its impact on treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients co-infected with HIV and HBV, potentially improving their health outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the dynamics of HBV in co-infected patients, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Grudda, Tanner — Johns Hopkins University
- Study coordinator: Grudda, Tanner
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.