Understanding how heparan sulfate affects cell functions and diseases
Official title: Heparan sulfate co-polymerase function and defects in disease
Funded at University of Georgia · NIH-10937607 · Data updated 2026-11-12
This study is looking at how certain chains on our cells, called heparan sulfate, are made and how problems with their production can lead to conditions like hereditary multiple exostoses, so that patients can learn more about their condition and possible new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $332,957 |
| NIH project number | 1R01GM154846-01 |
| Project ID | NIH-10937607 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with hereditary multiple exostoses or other conditions related to heparan sulfate dysfunction.
✕Less likely to help
Patients without any genetic predisposition to heparan sulfate-related conditions may not benefit from this research.
What this research studies
This research investigates the role of heparan sulfate chains found on cell surfaces and in extracellular matrices, which are crucial for various cellular processes such as survival, migration, and differentiation. The study focuses on the biosynthesis of heparan sulfate, particularly the function of the EXT1-EXT2 co-polymerase complex, which is essential for the proper formation of these chains. By examining the structure and function of this complex, the research aims to uncover how defects in heparan sulfate synthesis can lead to conditions like hereditary multiple exostoses and other diseases. Patients may benefit from insights gained into the mechanisms of these conditions and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases associated with heparan sulfate defects, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the role of heparan sulfate in various diseases, indicating that this approach has potential for success.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Moremen, Kelley W. — University of Georgia
- Study coordinator: Moremen, Kelley W.
Related research
Other NIH-funded projects on the same topics.
-
BRD4 and NIPBL work together to control facial bone development
A study in mice and cell models will explore how BRD4 and NIPBL work together to control how genes are turned on in facial development, which could clarify causes of craniofacial disorders.
-
Sulfated glycosaminoglycan hydrogels to protect brain volume after traumatic injury
A new implantable gel made from specially sulfated sugars may help prevent brain shrinkage and improve function after a serious brain injury.
-
Understanding how Kaposi’s sarcoma virus switches on late genes during infection
Scientists are studying how the virus causing Kaposi’s sarcoma turns on late genes when its DNA copies itself, which could reveal new ways to treat cancer in people with AIDS.
-
Understanding how cells control signals and adhesion with the secretory pathway
A funded NIH project looks at how the cell’s secretory system shapes signals, receptors, and attachment to the outside of the cell, which can influence many human diseases.
-
AI-powered math and machine learning for bioscience and drug discovery
A broad NIH grant supports using advanced math and AI to better predict viral variants and aid drug discovery, with the goal of helping patients by accelerating pandemic response.
-
AI-driven platform to predict vaccine-escape variants and design mutation-proof antibodies
An AI-powered approach aims to anticipate SARS-CoV-2 variants that may dodge vaccines and to create antibodies that stay effective.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.