Understanding how heparan sulfate affects cell functions and diseases
Heparan sulfate co-polymerase function and defects in disease
This study is looking at how certain chains on our cells, called heparan sulfate, are made and how problems with their production can lead to conditions like hereditary multiple exostoses, so that patients can learn more about their condition and possible new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-10937607 on NIH RePORTER |
What this research studies
This research investigates the role of heparan sulfate chains found on cell surfaces and in extracellular matrices, which are crucial for various cellular processes such as survival, migration, and differentiation. The study focuses on the biosynthesis of heparan sulfate, particularly the function of the EXT1-EXT2 co-polymerase complex, which is essential for the proper formation of these chains. By examining the structure and function of this complex, the research aims to uncover how defects in heparan sulfate synthesis can lead to conditions like hereditary multiple exostoses and other diseases. Patients may benefit from insights gained into the mechanisms of these conditions and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with hereditary multiple exostoses or other conditions related to heparan sulfate dysfunction.
Not a fit: Patients without any genetic predisposition to heparan sulfate-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases associated with heparan sulfate defects, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of heparan sulfate in various diseases, indicating that this approach has potential for success.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Moremen, Kelley W. — University of Georgia
- Study coordinator: Moremen, Kelley W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.