Understanding how hemolysis affects pulmonary hypertension
Hemolysis and Free Heme Signaling in Pulmonary Hypertension
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11176312
This study is looking at how the breakdown of red blood cells might contribute to high blood pressure in the lungs for people with sickle cell disease and thalassemia, and it hopes to find new ways to help manage this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11176312 on ClinicalTrials.gov |
What this research studies
This research investigates the role of hemolysis, or the breakdown of red blood cells, in the development of pulmonary hypertension (PH), particularly in patients with sickle cell disease and thalassemia. The study aims to uncover how free heme, released during hemolysis, influences cellular signaling in the pulmonary vasculature, potentially leading to worsening PH. By identifying the mechanisms through which heme affects endothelial cells, the research seeks to provide insights into new therapeutic targets for managing PH in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with sickle cell disease or thalassemia who are at risk of developing pulmonary hypertension.
Not a fit: Patients without hemolytic conditions or those who do not have pulmonary hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the mechanisms of pulmonary hypertension in patients with hemolytic conditions.
How similar studies have performed: Previous studies have shown promising results in understanding the role of hemolysis in pulmonary hypertension, indicating that this research builds on established findings.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAFIKOV, RUSLAN — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: RAFIKOV, RUSLAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.