Understanding how hemolysis affects platelet activation in sickle cell disease
Mechanisms of platelet stimulation in hemolysis
['FUNDING_CAREER'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11026403
This study is looking at how the breakdown of red blood cells affects blood platelets in people with sickle cell disease, focusing on a protein called HMGB1 that might make platelets more active and increase the risk of blood clots, with the goal of finding new ways to help manage the condition.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11026403 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which hemolysis, a breakdown of red blood cells, influences platelet activation in patients with sickle cell disease (SCD). It focuses on the role of inflammatory signals, particularly a protein called HMGB1, which is elevated in SCD patients and may enhance platelet activation. The study aims to explore how hemoglobin released during hemolysis interacts with HMGB1 to increase the production of reactive oxygen species in platelets, potentially leading to increased risk of thrombosis and related complications. By understanding these mechanisms, the research seeks to identify new therapeutic targets for managing SCD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with sickle cell disease who experience complications related to thrombosis.
Not a fit: Patients without sickle cell disease or those not experiencing complications related to thrombosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce the risk of thrombosis and related complications in sickle cell disease patients.
How similar studies have performed: Previous research has shown that inflammatory mediators play a significant role in platelet activation, suggesting that this approach may yield valuable insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NOLFI-DONEGAN, DEIRDRE — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: NOLFI-DONEGAN, DEIRDRE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Blood Platelet Disorders